A comparison of tumor-related antigens in male and female breast cancer.
Publication/Presentation Date
1-1-1986
Abstract
A retrospective analysis was undertaken in which 15 female and 15 male breast cancers were matched by age, stage, estrogen receptor status, and histologic type. Our protocol compares male and female breast cancers for reactivity with antibodies against tumor-associated antigens known to be present on female breast cancer cells. Formalin-fixed sections of each primary tumor were reacted in the ABC immunoperoxidase assay against antibodies B72.3 and DF.3 and an antibody to the ras p21 antigen. Reactivity to B72.3 and DF.3 was similar. However, the ras p21 antigen was expressed to a significantly greater extent in female breast cancers (p = .0008). Thus, although there are similarities in antigenic phenotype of male and female breast cancers, some female breast cancers may have a different pathogenesis as demonstrated by increased amounts of a specific oncogene product.
Volume
7
Issue
2
First Page
91
Last Page
96
ISSN
0167-6806
Published In/Presented At
Lundy, J., Mishriki, Y., Viola, M. V., Chao, S., Kasa, B., Oravez, S., & Schuss, A. (1986). A comparison of tumor-related antigens in male and female breast cancer. Breast cancer research and treatment, 7(2), 91–96. https://doi.org/10.1007/BF01806793
Disciplines
Medicine and Health Sciences
PubMedID
2424526
Department(s)
Department of Medicine
Document Type
Article