Immunocytochemistry with monoclonal antibody B72.3 applied to a spectrum of benign and malignant breast aspirates--strengths and pitfalls.
Publication/Presentation Date
12-1-1988
Abstract
Fine needle aspiration cytology (FNA) was performed on 168 breast masses. In all cases aspirates were reacted with monoclonal antibody (MAb) B72.3 using the ABC immunoperoxidase technique. MAb B72.3 demonstrated reactivity in nine of 90 malignant cases in which the cytologic diagnosis was not positive. In eight benign cases in which the cytopathologist made a suspicious diagnosis, MAb B72.3 demonstrated cytoplasmic reactivity in only one case. In three cytologically benign cases MAb B72.3 reacted strongly positive. The overall diagnostic accuracy of this immunoperoxidase technique was approximately 95 percent. In about five to 10 percent of cases, monoclonal antibody B72.3 can be a valuable diagnostic adjunct to routine cytopathologic diagnosis. False positives present pitfalls that must be considered.
Volume
12
Issue
3
First Page
259
Last Page
266
ISSN
0167-6806
Published In/Presented At
Lundy, J., Lozowski, M., & Mishriki, Y. (1988). Immunocytochemistry with monoclonal antibody B72.3 applied to a spectrum of benign and malignant breast aspirates--strengths and pitfalls. Breast cancer research and treatment, 12(3), 259–266. https://doi.org/10.1007/BF01811238
Disciplines
Medicine and Health Sciences
PubMedID
3067786
Department(s)
Department of Medicine
Document Type
Article