The use of fine-needle aspirates of breast cancers to evaluate hormone-receptor status.
Publication/Presentation Date
2-1-1990
Abstract
The objective of this study was to determine the reliability of immunocytochemical assays of hormone receptors using specimens obtained by fine-needle aspiration of breast cancers. A peroxidase-antiperoxidase immunocytochemical assay was used on 96 aspirates from 47 patients to determine estrogen and progesterone receptor status. Of 27 estrogen receptor-positive cases by steroid-binding analysis, 25 were positive by immunocytochemical assay. Of 21 estrogen receptor-negative cases, 17 were negative by immunocytochemical assay. Of 21 progesterone receptor-positive cases 19 were positive by immunocytochemical assay. Of 27 progesterone receptor-negative cases 25 were negative by immunocytochemical assay. An additional 11 small tumors were evaluated by immunocytochemical assay alone and results were interpretable based on our prior data. With the caveat that a cellular aspirate is obtained, immunocytochemical assay can distinguish hormone receptor-negative and hormone receptor-positive tumors and can be used to assay tumors too small for standard steroid-binding analysis.
Volume
125
Issue
2
First Page
174
Last Page
176
ISSN
0004-0010
Published In/Presented At
Lundy, J., Lozowski, M., Sadri, D., & Mishriki, Y. (1990). The use of fine-needle aspirates of breast cancers to evaluate hormone-receptor status. Archives of surgery (Chicago, Ill. : 1960), 125(2), 174–176. https://doi.org/10.1001/archsurg.1990.01410140048009
Disciplines
Medicine and Health Sciences
PubMedID
2302058
Department(s)
Department of Medicine
Document Type
Article