Terminal Ileitis as a Feature of Henoch-Schönlein Purpura Masquerading as Crohn Disease in Adults.
Publication/Presentation Date
3-1-2016
Abstract
Henoch-Schönlein purpura (HSP), more recently termed immunoglobulin A (IgA) vasculitis, is a systemic small-vessel vasculitis characterized by perivascular IgA deposition. This disease manifests clinically as palpable purpura, arthralgia, gastrointestinal symptoms, and renal dysfunction. Although ileitis can be seen in HSP, terminal ileitis is virtually pathognomonic for Crohn disease. We present a comprehensive review of the literature on this association, including 2 cases of our own, to demonstrate the importance of considering HSP in the differential diagnosis of ileitis suggestive of Crohn disease. We review the growing body of literature suggesting a pathophysiologic link between the conditions, possibly through an IgA-mediated mechanism.
Volume
22
Issue
2
First Page
82
Last Page
85
ISSN
1536-7355
Published In/Presented At
Sampat, H. N., McAllister, B. P., Gaines, D. D., & Ostrov, B. (2016). Terminal Ileitis as a Feature of Henoch-Schönlein Purpura Masquerading as Crohn Disease in Adults. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 22(2), 82–85. https://doi.org/10.1097/RHU.0000000000000361
Disciplines
Medicine and Health Sciences
PubMedID
26906301
Department(s)
Department of Medicine
Document Type
Article