Current and Emerging Therapies for Non-alcoholic Fatty Liver Disease.
Publication/Presentation Date
1-1-2019
Abstract
Non-alcoholic fatty liver disease is the most common cause of chronic liver disease in the developed world and commonly associated with metabolic comorbidities such as diabetes mellitus, hypertension, dyslipidemia, and obesity. Non-alcoholic steatohepatitis is an aggressive form of non-alcoholic fatty liver disease, associated with an increased risk of liver and non-liver-related mortality. Currently there are no approved therapies for non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and standard-of-care lifestyle advice is rarely effective. This has spurned intense drug development efforts and several agents are in clinical trials to address this major gap in non-alcoholic fatty liver disease. Drug development efforts have focused on pathogenic mechanisms including pathways involving lipid metabolism, inflammation, and fibrosis. This review presents the overview of the trials and agents in the pipeline of emerging therapies for non-alcoholic fatty liver disease/non-alcoholic steatohepatitis.
Volume
79
Issue
1
First Page
75
Last Page
84
ISSN
1179-1950
Published In/Presented At
Patel, S. S., & Siddiqui, M. S. (2019). Current and Emerging Therapies for Non-alcoholic Fatty Liver Disease. Drugs, 79(1), 75–84. https://doi.org/10.1007/s40265-018-1040-1
Disciplines
Medicine and Health Sciences
PubMedID
30588564
Department(s)
Department of Medicine
Document Type
Article