Progression to Cirrhosis Leads to Improvement in Atherogenic Milieu.
Publication/Presentation Date
1-1-2021
Abstract
INTRODUCTION: The prevalence of coronary artery disease (CAD) is high among patients with cirrhosis; however, the impact of it on cardiovascular disease (CVD) is not known. The aim of the current study was to evaluate CVD events in patients with cirrhosis and impact of cirrhosis on biomarkers of atherogenesis.
METHODS: The study included 682 patients with decompensated cirrhosis referred for liver transplantation (LT) evaluation between 2010 and 2017. All patients were followed until they experienced a CVD event, non-cardiac death, liver transplantation or last follow-up. To evaluate mechanistic link, patients with NASH cirrhosis were propensity matched 1:2 to non-cirrhosis NASH patients and biomarkers of atherogenic risk were compared.
RESULTS: The composite CVD outcome occurred in 23(3.4%) patients after a median follow-up period of 585 days (IQR 139, 747). A strong association between presence of any CAD and CVD event was noted (HR = 6.8, 95% CI 2.9, 15.9) that was independent of age, gender, BMI, and MELD score. In competing risk model, the combined rate of LT and non-cardiac was significantly higher when compared to the rate of CVD events. Marker of insulin resistance and inflammation-related markers were similar in patients with and without cirrhosis. Patients with cirrhosis were more likely to have reduced VLDL, sdLDL-C, LDL-C, and triglycerides. Interestingly, patients with cirrhosis had an increase in serum HDL-2, the anti-atherogenic lipoprotein, and adiponectin, a protective serum adipokine.
CONCLUSION: The risk of CVD events in patients with cirrhosis is low and may potentially be due to improvement in markers of atherogenic risk.
Volume
66
Issue
1
First Page
263
Last Page
272
ISSN
1573-2568
Published In/Presented At
Patel, S., Siddiqui, M. B., Chandrakumaran, A., Rodriguez, V. A., Faridnia, M., Hernandez Roman, J., Zhang, E., Patrone, M. V., Kakiyama, G., Walker, C., Sima, A., Minniti, R. J., Boyett, S., Bajaj, J. S., Sanyal, A., Pandak, W. M., Bhati, C., & Siddiqui, M. S. (2021). Progression to Cirrhosis Leads to Improvement in Atherogenic Milieu. Digestive diseases and sciences, 66(1), 263–272. https://doi.org/10.1007/s10620-020-06196-4
Disciplines
Medicine and Health Sciences
PubMedID
32189102
Department(s)
Department of Medicine
Document Type
Article