Congenital leukemia cutis.
Publication/Presentation Date
1-1-2008
Abstract
We describe a premature neonate who was born with pancytopenia and a single subcutaneous nodule on her right lower extremity. A biopsy specimen from the nodule demonstrated a dense infiltrate of pleomorphic mononuclear cells that extended throughout the dermis and into the subcutaneous tissue. Immunohistochemical stains and bone marrow examination confirmed a diagnosis of acute myelogenous leukemia. Cytogenetic studies on peripheral blood by G-banding analysis revealed an abnormal karyotype of 46, XX, ins[inv(10)(p11.2q22.2);11](q22.2;q13.2q23.2). A split in the mixed lineage leukemia gene was identified by fluorescence in situ hybridization. Induction chemotherapy was started but was complicated by multiorgan failure. The patient died on the eleventh day of life. As leukemia cutis more typically presents as multiple infiltrative papules, nodules, or plaques, we stress the importance of including leukemia in the differential diagnosis of a solitary nodule in a neonate.
Volume
25
Issue
1
First Page
34
Last Page
37
ISSN
1525-1470
Published In/Presented At
Fender, A. B., Gust, A., Wang, N., Scott, G. A., & Mercurio, M. G. (2008). Congenital leukemia cutis. Pediatric dermatology, 25(1), 34–37. https://doi.org/10.1111/j.1525-1470.2007.00578.x
Disciplines
Medicine and Health Sciences
PubMedID
18304150
Department(s)
Department of Medicine
Document Type
Article