Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities.
Publication/Presentation Date
10-1-2009
Abstract
A perineurioma is a benign peripheral nerve sheath neoplasm thought to be derived from cells of the perineurium, the cellular sheathing of peripheral nerve fascicles. The histological, immunohistochemical (positive for epithelial membrane antigen, collagen type IV, laminin and vimentin but not S-100 protein) and ultrastructural features of a perineurioma form the basis for diagnosis. Two types of perineuriomas are recognized, intraneural and soft tissue (extraneural) forms. Sclerosing perineurioma is considered a variant of the soft tissue perineurioma. In all but one of the reported cases, this subtype presented as a solitary clinical lesion with a predilection for the fingers and palms of young adults. In 2002, Huang and Sung described a 16-year-old boy with one sclerosing perineurioma on each hand. The unusual case presented herein is a 21-year-old woman manifesting more than 30 cutaneous sclerosing perineuriomas on the hands and arms. This case is the most extensive presentation of sclerosing perineuriomas documented to date and extends the clinical presentation spectrum of these lesions.
Volume
36 Suppl 1
First Page
60
Last Page
65
ISSN
1600-0560
Published In/Presented At
Rubin, A. I., Yassaee, M., Johnson, W., Elenitsas, R., Zaladonis, J., Jr, & Seykora, J. T. (2009). Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities. Journal of cutaneous pathology, 36 Suppl 1, 60–65. https://doi.org/10.1111/j.1600-0560.2008.01217.x
Disciplines
Medicine and Health Sciences
PubMedID
19187114
Department(s)
Department of Medicine
Document Type
Article