Porokeratosis and cutaneous malignancy. A review.
Publication/Presentation Date
4-1-1996
Abstract
BACKGROUND: Porokeratosis is a disorder of epidermal keratinization manifested clinically by a raised border and histologically by a cornoid lamella. While cutaneous malignancy has been reported to arise in porokeratosis, the risk remains unknown. In the past it has been associated with a history of radiation therapy.
OBJECTIVE: The purpose of this study is to estimate the frequency of cutaneous malignancy arising in porokeratosis and define those patients who are at highest risk.
METHODS: All cases in the English language literature in the last 30 years were reviewed.
RESULTS: Twenty-one (7.5%) of 281 cases reported revealed a malignancy arising within porokeratosis. Large lesions, those of long-standing duration, and the linear type were at greatest risk. Radiation therapy was an infrequently identified risk factor.
CONCLUSION: Porokeratosis is a premalignant condition, with certain groups of patients at greatest risk for malignant transformation.
Volume
22
Issue
4
First Page
339
Last Page
342
ISSN
1076-0512
Published In/Presented At
Sasson, M., & Krain, A. D. (1996). Porokeratosis and cutaneous malignancy. A review. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 22(4), 339–342. https://doi.org/10.1111/j.1524-4725.1996.tb00327.x
Disciplines
Medicine and Health Sciences
PubMedID
8624658
Department(s)
Department of Medicine
Document Type
Article