Improvement of severe systemic sclerosis-associated gastric antral vascular ectasia following immunosuppressive treatment with intravenous cyclophosphamide.
Publication/Presentation Date
8-1-2009
Abstract
OBJECTIVE: We describe 3 patients with systemic sclerosis (SSc) with severe, transfusion-dependent gastric antral vascular ectasia (GAVE) refractory to laser ablation who showed remarkable clinical and endoscopic improvement following intravenous (IV) pulse cyclophosphamide (CYC) treatment.
METHODS: Review of clinical records and upper gastrointestinal endoscopy images from 3 patients with SSc and severe GAVE before and after treatment with IV pulse CYC.
RESULTS: IV CYC was followed by improvement and stabilization of hemoglobin levels, and marked reduction in blood transfusion requirements and the number and frequency of endoscopic laser treatments.
CONCLUSION: IV pulse CYC immunosuppression was followed by remarkable clinical and endoscopic improvement of SSc-associated GAVE.
Volume
36
Issue
8
First Page
1653
Last Page
1656
ISSN
0315-162X
Published In/Presented At
Schulz, S. W., O'Brien, M., Maqsood, M., Sandorfi, N., Del Galdo, F., & Jimenez, S. A. (2009). Improvement of severe systemic sclerosis-associated gastric antral vascular ectasia following immunosuppressive treatment with intravenous cyclophosphamide. The Journal of rheumatology, 36(8), 1653–1656. https://doi.org/10.3899/jrheum.081247
Disciplines
Medicine and Health Sciences
PubMedID
19605670
Department(s)
Department of Medicine
Document Type
Article