Preeclampsia and angiogenic imbalance.
Publication/Presentation Date
1-1-2008
Abstract
Preeclampsia is a systemic syndrome of pregnancy that originates in the placenta and is characterized by widespread maternal endothelial dysfunction. Until recently, the molecular pathogenesis of preeclampsia was largely unknown, but recent work suggests a key role for altered expression of placental antiangiogenic factors. Soluble Flt1 and soluble endoglin, secreted by the placenta, are increased in the maternal circulation weeks before the onset of preeclampsia. These antiangiogenic factors produce systemic endothelial dysfunction, resulting in hypertension, proteinuria, and the other systemic manifestations of preeclampsia. The molecular basis for placental dysregulation of these pathogenic factors remains unknown, and the role of angiogenic proteins in early placental vascular development is just beginning to be explored. These discoveries have exciting clinical implications and are likely to transform the detection and treatment of preeclampsia in the future.
Volume
59
First Page
61
Last Page
78
ISSN
0066-4219
Published In/Presented At
Maynard, S., Epstein, F. H., & Karumanchi, S. A. (2008). Preeclampsia and angiogenic imbalance. Annual review of medicine, 59, 61–78. https://doi.org/10.1146/annurev.med.59.110106.214058
Disciplines
Medicine and Health Sciences
PubMedID
17937587
Department(s)
Department of Medicine
Document Type
Article