Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia.
Publication/Presentation Date
5-1-2005
Abstract
Preeclampsia, a pregnancy-specific syndrome of hypertension and proteinuria, is characterized by defective placental vasculogenesis and widespread maternal endothelial dysfunction. Although the manifestations of preeclampsia are primarily maternal, the burden of morbidity and mortality is often on the neonate, since the only effective treatment-delivery of the fetus and placenta-often results in iatrogenic prematurity. In this review, we summarize recent advances in our understanding of the pathophysiology of preeclampsia, including normal and aberrant placental vascular development and evidence for endothelial dysfunction. We describe recent evidence that supports a novel mechanism in which a maladaptive shift in placental production of angiogenic factors such as soluble fms-like tyrosine kinase 1 (a circulating antiangiogenic protein) may play an important role in the pathogenesis of preeclampsia.
Volume
57
Issue
5 Pt 2
First Page
1
Last Page
1
ISSN
0031-3998
Published In/Presented At
Maynard, S. E., Venkatesha, S., Thadhani, R., & Karumanchi, S. A. (2005). Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia. Pediatric research, 57(5 Pt 2), 1R–7R. https://doi.org/10.1203/01.PDR.0000159567.85157.B7
Disciplines
Medicine and Health Sciences
PubMedID
15817508
Department(s)
Department of Medicine
Document Type
Article