Angiogenic factors for the prediction of preeclampsia in high-risk women.
OBJECTIVE: The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women.
STUDY DESIGN: We collected serial serum specimens from 94 women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) were measured by enzyme-linked immunosorbent assay.
RESULTS: Mean serum sFlt1 and the sFlt1/PlGF ratio were higher in subjects who developed early-onset (less than 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks gestation onward. In subjects who developed late-onset (34 weeks or later) preeclampsia, sFlt1 was significantly increased after 31 weeks' gestation. The sFlt1/PlGF ratio at 22-26 weeks was highly predictive of early-onset preeclampsia. The within-woman rate of change of the sFlt1/PlGF ratio was predictive of overall preeclampsia risk.
CONCLUSIONS: In high-risk women, serum sFlt1 and the sFlt1:PlGF ratio are altered prior to preeclampsia onset and may be predictive of preeclampsia. Larger studies are needed to confirm these findings.
Published In/Presented At
Moore Simas, T. A., Crawford, S. L., Solitro, M. J., Frost, S. C., Meyer, B. A., & Maynard, S. E. (2007). Angiogenic factors for the prediction of preeclampsia in high-risk women. American journal of obstetrics and gynecology, 197(3), 244.e1–244.e2448. https://doi.org/10.1016/j.ajog.2007.06.030
Medicine and Health Sciences
Department of Medicine