Dendritic cell vaccines.
Publication/Presentation Date
5-1-2007
Abstract
Dendritic cells are antigen-presenting cells that have been shown to stimulate tumor antigen-specific T cell responses in preclinical studies. Consequently, there has been intense interest in developing dendritic cell based cancer vaccines. A variety of methods for generating dendritic cells, loading them with tumor antigens, and administering them to patients have been described. In recent years, a number of early phase clinical trials have been performed and have demonstrated the safety and feasibility of dendritic cell immunotherapies. A number of these trials have generated valuable preliminary data regarding the clinical and immunologic response to DC-based immunotherapy. The emphasis of dendritic cell immunotherapy research is increasingly shifting toward the development of strategies to increase the potency of dendritic cell vaccine preparations.
Volume
12
First Page
4050
Last Page
4060
ISSN
1093-9946
Published In/Presented At
Mosca, P. J., Lyerly, H. K., Clay, T. M., Morse, M. A., & Lyerly, H. K. (2007). Dendritic cell vaccines. Frontiers in bioscience : a journal and virtual library, 12, 4050–4060. https://doi.org/10.2741/2371
Disciplines
Medicine and Health Sciences
PubMedID
17485358
Department(s)
Department of Medicine
Document Type
Article