Effects of tetracyclines on aldosterone- and insulin-mediated Na+ transport in the toad urinary bladder.
Publication/Presentation Date
3-23-1979
Abstract
The effect of oxytetracycline and demethylchlortetracycline on aldosterone- and insulin-mediated Na+ transport (short-circuit current) were examined in toad urinary bladders mounted in modified Ussing chambers. Oxytetracycline had little or no effect on either basal or aldosterone-mediated Na+ transport. In contrast, demethylchlortetracycline markedly inhibited both basal and aldosterone-mediated Na+ transport. Furthermore, demethylchlortetracycline inhibited the aldosterone response significantly out of proportion to its effects on basal Na+ transport. Neither of the drugs had an effect on insulin-mediated Na+ transport. Consequently, the natriuresis observed in certain patients treated with demethylchlortetracyline may be related to drug-induced renal resistance to the effects of aldosterone.
Volume
552
Issue
1
First Page
162
Last Page
168
ISSN
0006-3002
Published In/Presented At
Cox, M., Guzzo, J., Shook, A., Huber, G., & Singer, I. (1979). Effects of tetracyclines on aldosterone- and insulin-mediated Na+ transport in the toad urinary bladder. Biochimica et biophysica acta, 552(1), 162–168. https://doi.org/10.1016/0005-2736(79)90254-2
Disciplines
Medicine and Health Sciences
PubMedID
107969
Department(s)
Department of Medicine
Document Type
Article