Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals.
Publication/Presentation Date
11-1-2017
Abstract
ERK-dependent signaling is key to many pathways through which extracellular signals are transduced into cell-fate decisions. One conundrum is the way in which disparate signals induce specific responses through a common, ERK-dependent kinase cascade. While studies have revealed intricate ways of controlling ERK signaling through spatiotemporal localization and phosphorylation dynamics, additional modes of ERK regulation undoubtedly remain to be discovered. We hypothesized that fine-tuning of ERK signaling could occur by cysteine oxidation. We report that ERK is actively and directly oxidized by signal-generated H
Volume
112
First Page
534
Last Page
543
ISSN
1873-4596
Published In/Presented At
Keyes, J. D., Parsonage, D., Yammani, R. D., Rogers, L. C., Kesty, C., Furdui, C. M., Nelson, K. J., & Poole, L. B. (2017). Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals. Free radical biology & medicine, 112, 534–543. https://doi.org/10.1016/j.freeradbiomed.2017.08.018
Disciplines
Medicine and Health Sciences
PubMedID
28843779
Department(s)
Department of Medicine, Department of Medicine Fellows and Residents, Fellows and Residents
Document Type
Article