Chronic mineralocorticoid excess and cardiovascular remodeling.
Publication/Presentation Date
1-1-1995
Abstract
Chronic mineralocorticoid (MC) excess, whether due to elevated plasma aldosterone (ALDO) or deoxycorticosterone (DOC), is associated with a perivascular fibrosis of systemic and coronary arterioles. This remodeling of resistance vessels contributes to the appearance of hypertension. Chronic MC excess is also accompanied by cardiac myocyte necrosis, secondary to myocardial potassium depletion, and a subsequent reparative fibrosis that appears in the normotensive, nonhypertrophied right and hypertensive, hypertrophied left ventricles. Fibrosis contributes to the appearance of ventricular arrhythmias and dysfunction. Herein, clinical and experimental evidence linking chronic, inappropriate (relative to dietary sodium) elevations in circulating ALDO and DOC with these reactive and reparative forms of fibrous tissue formation in the heart and other tissues is presented.
Volume
60
Issue
1
First Page
125
Last Page
132
ISSN
0039-128X
Published In/Presented At
Weber KT, Sun Y, Campbell SE, Slight SH, Ganjam VK, Griffing GT, Swinfard RW, Diaz-Arias AA. Chronic mineralocorticoid excess and cardiovascular remodeling. Steroids. 1995 Jan;60(1):125-32. doi: 10.1016/0039-128x(94)00030-g. PMID: 7792797.
Disciplines
Medicine and Health Sciences
PubMedID
7792797
Department(s)
Department of Medicine
Document Type
Article