Conversions between monotherapies in epilepsy: expert consensus.
Publication/Presentation Date
9-1-2007
Abstract
To develop expert consensus for conversion between antiepileptic drug (AED) monotherapies, an 11-member panel used the Delphi Technique over three rounds to: (1) identify relevant issues, (2) vote on the issues, and (3) develop consensus. The panel agreed on the basic principle to taper the existing AED only after a presumably efficacious dose of the planned AED was reached. Application is modified by adverse effects possibly attributable to the existing drug, in which case earlier or more rapid tapering of the existing drug should be considered. Patients with uncontrolled seizures, as well as seizure-free patients for whom driving privileges are a consideration, may benefit from slower tapering by smaller dosage decrements of the existing AED. For 10 of the 12 AEDs considered, the panel made titration recommendations concerning initial and target doses for the planned AED, supplementing limited data in the prescribing information. This expert guidance will aid in the period of transitional polytherapy with AEDs from monotherapy to monotherapy.
Volume
11
Issue
2
First Page
222
Last Page
234
ISSN
1525-5050
Published In/Presented At
St Louis, E. K., Gidal, B. E., Henry, T. R., Kaydanova, Y., Krumholz, A., McCabe, P. H., Montouris, G. D., Rosenfeld, W. E., Smith, B. J., Stern, J. M., Waterhouse, E. J., Schulz, R. M., Garnett, W. R., & Bramley, T. (2007). Conversions between monotherapies in epilepsy: expert consensus. Epilepsy & behavior : E&B, 11(2), 222–234. https://doi.org/10.1016/j.yebeh.2007.04.007
Disciplines
Medicine and Health Sciences
PubMedID
17586097
Department(s)
Department of Medicine
Document Type
Article