Anti-thymocyte globulin for conditioning in matched unrelated donor hematopoietic cell transplantation provides comparable outcomes to matched related donor recipients.
Publication/Presentation Date
12-1-2012
Abstract
Rabbit anti-thymocyte globulin (ATG) is used as prophylaxis against GVHD following allogeneic hematopoietic cell transplantation (HCT). At our institution, ATG is exclusively used in the conditioning of matched unrelated donor (URD) transplant recipients. A total of 50 URD HCT recipients who received ATG (ATG group) were retrospectively compared with 48 matched related donor (MRD) HCT recipients who did not receive ATG (no ATG group). There were no significant differences between the groups in rates of day 100 mortality, acute GVHD or relapse. Chronic GVHD incidence was significantly lower in the ATG group (P = 0.007). At a median follow-up of 36 months in the entire cohort, 50% patients are alive in the ATG group and 63% of the patients are alive in the no ATG group (P = 0.13). We conclude that the administration of ATG to patients undergoing URD HCT preserves the anti-leukemia benefit of the transplant, while reducing the risk of developing GVHD, resulting in OS rates that are comparable to MRD HCT recipients.
Volume
47
Issue
12
First Page
1513
Last Page
1519
ISSN
1476-5365
Published In/Presented At
Portier, D. A., Sabo, R. T., Roberts, C. H., Fletcher, D. S., Meier, J., Clark, W. B., Neale, M. C., Manjili, M. H., McCarty, J. M., Chung, H. M., & Toor, A. A. (2012). Anti-thymocyte globulin for conditioning in matched unrelated donor hematopoietic cell transplantation provides comparable outcomes to matched related donor recipients. Bone marrow transplantation, 47(12), 1513–1519. https://doi.org/10.1038/bmt.2012.81
Disciplines
Medicine and Health Sciences
PubMedID
22580767
Department(s)
Department of Medicine, Hematology-Medical Oncology Division
Document Type
Article