Acquired factor VII deficiency in hematopoietic stem cell transplant recipients.
Publication/Presentation Date
3-1-2002
Abstract
Acquired factor VII (FVII) deficiency in the absence of vitamin K deficiency, oral anticoagulant therapy, synthetic liver dysfunction, or DIC is rare, with only a handful of cases thus far reported. In the period from 1990 to 1996 we identified eight patients with acquired FVII deficiency, all of whom presented with prolongation of the prothrombin time (PT) in the first 2 weeks following stem cell transplantation (SCT). The mean plasma FVII clotting activity (FVII:c) was 22% (range 8-35%) with an approximately equivalent reduction in FVII antigen (FVII:Ag) level. Mean plasma levels of fibrinogen and factors II, V, IX, and X were normal. Protein C activity was significantly depressed in only one of the three patients in whom it was measured. Several patients experienced bleeding complications, and hemorrhage directly accounted for death in two cases. Veno-occlusive disease of the liver developed in three patients. We conclude that FVII deficiency should be considered in the differential diagnosis of prolonged PT in patients who have recently undergone SCT. The mechanism of this acquired deficiency state remains to be defined.
Volume
29
Issue
5
First Page
403
Last Page
408
ISSN
0268-3369
Published In/Presented At
Toor, A. A., Slungaard, A., Hedner, U., Weisdorf, D. J., & Key, N. S. (2002). Acquired factor VII deficiency in hematopoietic stem cell transplant recipients. Bone marrow transplantation, 29(5), 403–408. https://doi.org/10.1038/sj.bmt.1703381
Disciplines
Medicine and Health Sciences
PubMedID
11919730
Department(s)
Department of Medicine, Hematology-Medical Oncology Division
Document Type
Article