Regional brain function in schizophrenia. I. A positron emission tomography study.
Publication/Presentation Date
2-1-1987
Abstract
Local cerebral glucose metabolism was determined with 18-F-fluorodeoxyglucose using positron emission tomography in a sample of 12 unmedicated schizophrenics and 12 matched normal controls. The data were analyzed for absolute metabolic rates and region/whole-brain ratios using the cortical-subcortical, antero-posterior, and laterality dimensions. Lobar areas within cortical regions were also compared. Across groups, subcortical metabolism was higher than cortical metabolism. Patients had lower metabolism, cortically and subcortically, and a steeper subcortical to cortical gradient. Patients with higher scores on the Brief Psychiatric Rating Scale had higher absolute metabolism and higher left relative to right hemispheric metabolism than did patients with lesser severity. The results did not show "hypofrontality" in schizophrenia. These findings provide some support for cerebral dysfunction in schizophrenia and indicate the need for further examination of the cortical-subcortical dimension.
Volume
44
Issue
2
First Page
119
Last Page
125
ISSN
0003-990X
Published In/Presented At
Gur, R. E., Resnick, S. M., Alavi, A., Gur, R. C., Caroff, S., Dann, R., Silver, F. L., Saykin, A. J., Chawluk, J. B., & Kushner, M. (1987). Regional brain function in schizophrenia. I. A positron emission tomography study. Archives of general psychiatry, 44(2), 119–125. https://doi.org/10.1001/archpsyc.1987.01800140021003
Disciplines
Medicine and Health Sciences
PubMedID
3492982
Department(s)
Department of Medicine
Document Type
Article