Resolving metabolic abnormalities in a case of pure alexia.
Publication/Presentation Date
5-1-1988
Abstract
We report resolving metabolic abnormalities corresponding to clinical improvement in a patient with pure alexia secondary to acute cerebral infarction. Local cerebral glucose metabolism (lCMRgl) was measured with positron emission tomography (PET) using 18F-fluorodeoxyglucose (18F-FDG) close to ictus and 4 1/2 months later. Serial CTs and a subsequent MRI demonstrated small, unchanging left-hemispheric lesions involving the area of the lateral geniculate body and the splenium of the corpus callosum. PET demonstrated the evolution of the metabolic abnormality resulting from intrahemispheric (lateral geniculate) and interhemispheric (splenium) disconnection in the absence of occipital lobe infarction. This case illustrates that cerebral disconnection can result in the syndrome of pure alexia. The factors accounting for focal hypometabolism in the absence of cerebral infarction are discussed.
Volume
38
Issue
5
First Page
730
Last Page
735
ISSN
0028-3878
Published In/Presented At
Silver, F. L., Chawluk, J. B., Bosley, T. M., Rosen, M., Dann, R., Sergott, R. C., Alavi, A., & Reivich, M. (1988). Resolving metabolic abnormalities in a case of pure alexia. Neurology, 38(5), 730–735. https://doi.org/10.1212/wnl.38.5.730
Disciplines
Medicine and Health Sciences
PubMedID
3258969
Department(s)
Department of Medicine
Document Type
Article