Positron emission tomography in the investigation of central nervous system disorders.
Publication/Presentation Date
9-1-1988
Abstract
Positron emission tomography is a noninvasive tomographic technique for measuring regional tissue concentrations of labeled radionuclides in man. Detection of two photons emitted from the annihilation of a positron and an electron is used to reconstruct the distribution of a positron-emitting isotope within an organ. PET provides the capacity to measure quantitatively the local tissue distribution of a variety of radionuclides that are attached to compounds that distribute according to function. Commonly measured functions include local cerebral metabolism using 18F-fluorodeoxyglucose or 11C-deoxyglucose, cerebral blood flow, cerebral oxygen utilization, and cerebral blood volume. Clinical applications of PET are multiple, involving normal and disease states. By demonstrating the metabolic alterations, PET adds another dimension to our understanding of the brain, which up until recently has been based on the structural changes seen on CT and MRI.
Volume
26
Issue
5
First Page
1075
Last Page
1088
ISSN
0033-8389
Published In/Presented At
Jamieson, D., Alavi, A., Jolles, P., Chawluk, J., & Reivich, M. (1988). Positron emission tomography in the investigation of central nervous system disorders. Radiologic clinics of North America, 26(5), 1075–1088.
Disciplines
Medicine and Health Sciences
PubMedID
3047777
Department(s)
Department of Medicine
Document Type
Article