Cerebral blood flow variations in CNS lupus.
Publication/Presentation Date
1-1-1990
Abstract
We studied the patterns of cerebral blood flow (CBF), over time, in patients with systemic lupus erythematosus and varying neurologic manifestations including headache, stroke, psychosis, and encephalopathy. For 20 paired xenon-133 CBF measurements, CBF was normal during CNS remissions, regardless of the symptoms. CBF was significantly depressed during CNS exacerbations. The magnitude of change in CBF varied with the neurologic syndrome. CBF was least affected in patients with nonspecific symptoms such as headache or malaise, whereas patients with encephalopathy or psychosis exhibited the greatest reductions in CBF. In 1 patient with affective psychosis, without clinical or CT evidence of cerebral ischemia, serial SPECT studies showed resolution of multifocal cerebral perfusion defects which paralleled clinical recovery.
Volume
40
Issue
1
First Page
99
Last Page
102
ISSN
0028-3878
Published In/Presented At
Kushner, M. J., Tobin, M., Fazekas, F., Chawluk, J., Jamieson, D., Freundlich, B., Grenell, S., Freemen, L., & Reivich, M. (1990). Cerebral blood flow variations in CNS lupus. Neurology, 40(1), 99–102. https://doi.org/10.1212/wnl.40.1.99
Disciplines
Medicine and Health Sciences
PubMedID
2296389
Department(s)
Department of Medicine
Document Type
Article