Metformin Inhibits Mouse Islet Insulin Secretion and Alters Intracellular Calcium in a Concentration-Dependent and Duration-Dependent Manner near the Circulating Range.
Publication/Presentation Date
1-1-2018
Abstract
Metformin is considered the first-line treatment for type 2 diabetes. While metformin primarily increases insulin sensitivity, evidence also suggests that metformin affects the activity of insulin-secreting pancreatic islets. This study was designed to systematically examine the direct effects of metformin by measuring insulin secretion and the kinetics of the calcium response to glucose stimulation in isolated mouse islets using varying concentrations (20
Volume
2018
First Page
9163052
Last Page
9163052
ISSN
2314-6753
Published In/Presented At
Gelin, L., Li, J., Corbin, K. L., Jahan, I., & Nunemaker, C. S. (2018). Metformin Inhibits Mouse Islet Insulin Secretion and Alters Intracellular Calcium in a Concentration-Dependent and Duration-Dependent Manner near the Circulating Range. Journal of diabetes research, 2018, 9163052. https://doi.org/10.1155/2018/9163052
Disciplines
Medicine and Health Sciences
PubMedID
29862303
Department(s)
Department of Medicine, Department of Medicine Fellows and Residents, Fellows and Residents
Document Type
Article