Lower motor neuron dysfunction in patients with multiple sclerosis.
Publication/Presentation Date
11-1-1992
Abstract
A patient in whom multiple sclerosis (MS) was ultimately diagnosed presented with a lower motor neuron syndrome involving 1 hand, with EMG evidence of denervation. Twelve other patients were subsequently identified with definite MS and asymmetric hand atrophy. These patients were studied clinically and electrophysiologically. Evidence of chronic and ongoing denervation was noted in the hands of 12 of the 13 patients; in only 3 patients could the EMG abnormalities be accounted for by peripheral nerve lesions. Thus, lesions resulting in lower motor neuron damage may occur in the central nervous system in MS patients. We suggest that demyelination in the region of the ventral root exit zone may account for these findings.
Volume
15
Issue
11
First Page
1265
Last Page
1270
ISSN
0148-639X
Published In/Presented At
Shefner, J. M., Mackin, G. A., & Dawson, D. M. (1992). Lower motor neuron dysfunction in patients with multiple sclerosis. Muscle & nerve, 15(11), 1265–1270. https://doi.org/10.1002/mus.880151108
Disciplines
Medicine and Health Sciences
PubMedID
1488064
Department(s)
Department of Medicine
Document Type
Article