Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden.
Publication/Presentation Date
11-1-1994
Abstract
We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a significant correlation between the change in EDSS or AI and the change in number of lesions on MRI and between cumulative number of lesions on MRI and cumulative change in EDSS or AI. Our findings support the validity of MRI as a measure of clinical activity and potentially as an objective quantitative outcome measure for assessing response to therapy.
Volume
44
Issue
11
First Page
2120
Last Page
2124
ISSN
0028-3878
Published In/Presented At
Khoury, S. J., Guttmann, C. R., Orav, E. J., Hohol, M. J., Ahn, S. S., Hsu, L., Kikinis, R., Mackin, G. A., Jolesz, F. A., & Weiner, H. L. (1994). Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. Neurology, 44(11), 2120–2124. https://doi.org/10.1212/wnl.44.11.2120
Disciplines
Medicine and Health Sciences
PubMedID
7969970
Department(s)
Department of Medicine
Document Type
Article