Syndrome of inappropriate antidiuresis in Waldenström's macroglobulinemia.
Publication/Presentation Date
6-1-1986
Abstract
Hyponatremia due to the syndrome of inappropriate antidiuresis rather than due to isotonic hyponatremia from hyperproteinemia developed in a patient with Waldenström's macroglobulinemia. The patient was unable to excrete a water load normally despite suppression of antidiuretic hormone to normal levels. The temporal relationship between control of the tumor and resolution of the hyponatremia suggests that the tumor either produced a substance that enhanced the hydro-osmotic effect of endogenous antidiuretic hormone or produced an antidiuretic substance immunologically different from antidiuretic hormone. The syndrome of inappropriate antidiuresis should be suspected in hyponatremic patients with Waldenström's macroglobulinemia.
Volume
80
Issue
6
First Page
1242
Last Page
1244
ISSN
0002-9343
Published In/Presented At
Braden GL, Mikolich DJ, White CF, Germain MJ, Fitzgibbons JP. Syndrome of inappropriate antidiuresis in Waldenström's macroglobulinemia. Am J Med. 1986 Jun;80(6):1242-4. doi: 10.1016/0002-9343(86)90696-0. PMID: 3088997.
Disciplines
Medicine and Health Sciences
PubMedID
3088997
Department(s)
Department of Medicine
Document Type
Article