Acute coronary vasoconstrictive effects of cigarette smoking in coronary heart disease.
Publication/Presentation Date
7-1-1984
Abstract
To investigate the effect of cigarette smoking on the coronary vasculature, coronary sinus flow and myocardial oxygen delivery were measured at rest and during incremental atrial pacing in 10 patients with coronary artery disease. Measurements were then repeated while the patients smoked 2 unfiltered, high-nicotine cigarettes. Although smoking significantly increased the heart rate at rest and double product, coronary sinus flow did not change significantly (141 +/- 32 vs 146 +/- 28 ml/min). At the lowest equivalent pacing rate before and during smoking, the double products were comparable. However, coronary sinus flow was reduced by smoking (146 +/- 28 vs 159 +/- 28 ml/min, p less than 0.01) and coronary vascular resistance was increased (0.96 +/- 0.15 vs 0.83 +/- 0.13 mm Hg ml-1 min, p less than 0.02). The double products were also comparable at the peak pacing rate before and during smoking. Nonetheless, the coronary sinus flow was again lower (167 +/- 23 vs 227 +/- 41 ml/min, p = 0.02) and the coronary vascular resistance was higher (0.77 +/- 0.10 vs 0.63 +/- 0.09 mm Hg ml-1 min, p less than 0.01) during smoking. The transmyocardial arteriovenous oxygen difference was unchanged by smoking; therefore, myocardial oxygen delivery was reduced in proportion to the reductions in coronary sinus flow. Thus, cigarette smoking appears to acutely alter the ability of the coronary vasculature to regulate flow in accordance with the oxygen requirements of the myocardium.
Volume
54
Issue
1
First Page
56
Last Page
60
ISSN
0002-9149
Published In/Presented At
Martin, J. L., Wilson, J. R., Ferraro, N., Laskey, W. K., Kleaveland, J. P., & Hirshfeld, J. W., Jr (1984). Acute coronary vasoconstrictive effects of cigarette smoking in coronary heart disease. The American journal of cardiology, 54(1), 56–60. https://doi.org/10.1016/0002-9149(84)90303-5
Disciplines
Medicine and Health Sciences
PubMedID
6741839
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article