Dendritic cell maturation in active immunotherapy strategies.
Publication/Presentation Date
1-1-2002
Abstract
Dendritic cells (DCs) loaded with tumour antigen have become the centrepiece of clinical trials testing active immunotherapy strategies. Important variables include the source of DCs, the choice of antigens, the method of antigen loading and the route and timing of administration. Recently, the requirement for and the method of, DC maturation have been receiving particular attention. This is due to observations from in vitro studies and animal models demonstrating that mature DCs induce more potent antigen-specific T-cells responses than immature DCs. Furthermore, preliminary observations in human studies suggest that immature DCs might actually downregulate antigen-specific T-cell responses but mature DCs may augment them. Current studies are addressing how to define DC maturation, whether the variety of methods for maturation result in DCs with similar T-cell stimulatory capacity, how to maintain the maturational status and whether maturation in vitro before immunisation, or in vivo, after immunisation, results in better DC function.
Volume
2
Issue
1
First Page
35
Last Page
43
ISSN
1471-2598
Published In/Presented At
Morse, M. A., Mosca, P. J., Clay, T. M., & Lyerly, H. K. (2002). Dendritic cell maturation in active immunotherapy strategies. Expert opinion on biological therapy, 2(1), 35–43. https://doi.org/10.1517/14712598.2.1.35
Disciplines
Medicine and Health Sciences
PubMedID
11772338
Department(s)
Department of Medicine
Document Type
Article