Current status of dendritic cell immunotherapy of malignancies.
Publication/Presentation Date
1-1-2003
Abstract
Because dendritic cells (DC) are central to the induction of antigen-specific T cell responses, their use for the active immunotherapy of malignancies has been of considerable interest. Since clinical trials with DC-based vaccines have been initiated, a number of important developmental issues have become apparent. These include the ideal source and type of DC, the form of antigen and method of loading DC, whether to induce maturation, the route and timing of immunization, and the optimal clinical scenario. Clinical responses such as stability of disease and tumor regressions have been reported in some patients, particularly with melanoma, myeloma, and prostate cancer.
Volume
22
Issue
3-4
First Page
255
Last Page
281
ISSN
0883-0185
Published In/Presented At
Mosca, P. J., Clay, T. M., Kim Lyerly, H., & Morse, M. A. (2003). Current status of dendritic cell immunotherapy of malignancies. International reviews of immunology, 22(3-4), 255–281. https://doi.org/10.1080/08830180305223
Disciplines
Medicine and Health Sciences
PubMedID
12745642
Department(s)
Department of Medicine
Document Type
Article