Hepatoid esophagogastric adenocarcinoma and tumoral heterogeneity: a case report.
Publication/Presentation Date
12-1-2021
Abstract
Hepatoid adenocarcinoma of the stomach is an uncommon subtype of gastric cancer remarkably similar to hepatocellular carcinoma in histopathological analysis. It is also commonly associated with high serum alfa-fetoprotein and a poorer prognosis, despite the emergence of new therapeutic options. In recent years, next generation sequencing (NGS) technology has made it possible to identify and describe the genes and molecular alterations common to gastric cancer thereby contributing to the advancement of targeted therapies. A 62-year-old patient, with no prior risk factor for hepatocellular carcinoma (HCC), presented to the emergency room with dysphagia for solids, abdominal pain and weight loss of about 3 kilograms over 3 months. Histopathological analysis presented with disparities regarding HER2 and programmed death-ligand 1 (PD-L1) status in the primary and metastatic sites. We describe a case of a
Volume
12
Issue
6
First Page
3123
Last Page
3132
ISSN
2078-6891
Published In/Presented At
de Castria, T. B., Tang, L., Queiroz, M. M., Awni, B. M., Paroder, V., Shamseddine, A., Bariani, G. M., Mukherji, D., Matar, C. F., Fernandes, G. D. S., El-Olayan, A., Sabatin, F., Elias, R., Gupta, R., Janjigian, Y. Y., & Abou-Alfa, G. K. (2021). Hepatoid esophagogastric adenocarcinoma and tumoral heterogeneity: a case report. Journal of gastrointestinal oncology, 12(6), 3123–3132. https://doi.org/10.21037/jgo-21-287
Disciplines
Medicine and Health Sciences
PubMedID
35070435
Department(s)
Department of Medicine, Hematology-Medical Oncology Division
Document Type
Article