Adverse Effects of Immunosuppression: Nephrotoxicity, Hypertension, and Metabolic Disease.

Publication/Presentation Date

1-1-2022

Abstract

The use of Immunosuppression has led to the tremendous improvement in graft survival. However, immunosuppressants have been found to cause a variety of metabolic derangements including but not limited to: insulin resistance and diabetes, hyperlipidemia, hypertension, and weight gain after transplantation. This combination of metabolic risk factors may be associated with increased cardiovascular disease (Grundy et al., Circulation 112(17):2735, 2005). In addition many transplant recipients may have many of these risk factors pre-transplant that are exacerbated by immunosuppression. These facts emphasize the need for rigorous follow-up and management of these risk factors post-transplant.The most common immune suppressant regimens may include different combinations of these agents: Corticosteroids, Calcineurin inhibitors (CNIs), Mammalian Target of Rapamycin (mTOR) Inhibitors, Antimetabolite.

Volume

272

First Page

337

Last Page

348

ISSN

0171-2004

Disciplines

Medicine and Health Sciences

PubMedID

34697665

Department(s)

Department of Medicine, Cardiology Division

Document Type

Article

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