Adverse Effects of Immunosuppression: Nephrotoxicity, Hypertension, and Metabolic Disease.
Publication/Presentation Date
1-1-2022
Abstract
The use of Immunosuppression has led to the tremendous improvement in graft survival. However, immunosuppressants have been found to cause a variety of metabolic derangements including but not limited to: insulin resistance and diabetes, hyperlipidemia, hypertension, and weight gain after transplantation. This combination of metabolic risk factors may be associated with increased cardiovascular disease (Grundy et al., Circulation 112(17):2735, 2005). In addition many transplant recipients may have many of these risk factors pre-transplant that are exacerbated by immunosuppression. These facts emphasize the need for rigorous follow-up and management of these risk factors post-transplant.The most common immune suppressant regimens may include different combinations of these agents: Corticosteroids, Calcineurin inhibitors (CNIs), Mammalian Target of Rapamycin (mTOR) Inhibitors, Antimetabolite.
Volume
272
First Page
337
Last Page
348
ISSN
0171-2004
Published In/Presented At
Hoosain, J., & Hamad, E. (2022). Adverse Effects of Immunosuppression: Nephrotoxicity, Hypertension, and Metabolic Disease. Handbook of experimental pharmacology, 272, 337–348. https://doi.org/10.1007/164_2021_547
Disciplines
Medicine and Health Sciences
PubMedID
34697665
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article