Incremental effects of diabetes mellitus and chronic kidney disease in medial arterial calcification: Synergistic pathways for peripheral artery disease progression.
Publication/Presentation Date
10-1-2019
Abstract
Diabetes mellitus (DM) and chronic kidney disease (CKD) separately are known to facilitate the progression of medial arterial calcification (MAC) in patients with symptomatic peripheral artery disease (PAD), but their combined effect on MAC and associated mediators of calcification is not well studied. The association of MAC and calcification inducer bone morphogenetic protein (BMP-2) and inhibitor fetuin-A, with PAD, is well known. Our aim was to investigate the association of MAC with alterations in BMP-2 and fetuin-A protein expression in patients with PAD with DM and/or CKD. Peripheral artery plaques (50) collected during directional atherectomy from symptomatic patients with PAD were evaluated, grouped into no-DM/no-CKD (
Volume
24
Issue
5
First Page
383
Last Page
394
ISSN
1477-0377
Published In/Presented At
Krishnan, P., Moreno, P. R., Turnbull, I. C., Purushothaman, M., Zafar, U., Tarricone, A., Singla, S., Kini, A., Sharma, S., Narula, J., Badimon, J. J., & Purushothaman, K. R. (2019). Incremental effects of diabetes mellitus and chronic kidney disease in medial arterial calcification: Synergistic pathways for peripheral artery disease progression. Vascular medicine (London, England), 24(5), 383–394. https://doi.org/10.1177/1358863X19842276
Disciplines
Medicine and Health Sciences
PubMedID
31090495
Department(s)
Department of Medicine
Document Type
Article