Incremental effects of diabetes mellitus and chronic kidney disease in medial arterial calcification: Synergistic pathways for peripheral artery disease progression.
Diabetes mellitus (DM) and chronic kidney disease (CKD) separately are known to facilitate the progression of medial arterial calcification (MAC) in patients with symptomatic peripheral artery disease (PAD), but their combined effect on MAC and associated mediators of calcification is not well studied. The association of MAC and calcification inducer bone morphogenetic protein (BMP-2) and inhibitor fetuin-A, with PAD, is well known. Our aim was to investigate the association of MAC with alterations in BMP-2 and fetuin-A protein expression in patients with PAD with DM and/or CKD. Peripheral artery plaques (50) collected during directional atherectomy from symptomatic patients with PAD were evaluated, grouped into no-DM/no-CKD (
Published In/Presented At
Krishnan, P., Moreno, P. R., Turnbull, I. C., Purushothaman, M., Zafar, U., Tarricone, A., Singla, S., Kini, A., Sharma, S., Narula, J., Badimon, J. J., & Purushothaman, K. R. (2019). Incremental effects of diabetes mellitus and chronic kidney disease in medial arterial calcification: Synergistic pathways for peripheral artery disease progression. Vascular medicine (London, England), 24(5), 383–394. https://doi.org/10.1177/1358863X19842276
Medicine and Health Sciences
Department of Medicine