Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis.
Publication/Presentation Date
1-29-2012
Abstract
Atherosclerosis is characterized by accumulation of lipids and inflammatory cells in the arterial wall. Oxidized low-density lipoprotein (ox-LDL) plays important role in the genesis and progression of atheromatous plaque. Various scavenger receptors have been recognized in the past two decades that mediate uptake of ox-LDL leading to formation of foam cells. Inhibition of scavenger receptor A and CD36 has been shown to affect progression of atherosclerosis by decreasing foam cell formation. Lectin-type oxidized LDL receptor 1 (LOX-1) participates at various steps involved in the pathogenesis of atherosclerosis, and in experimental studies its blockade has been shown to affect the progression of atherosclerosis at multiple levels. In this review, we summarize the role of ox-LDL and scavenger receptors in the formation of atheroma with emphasis on effects of LOX-1 blockade.
ISSN
1534-6242
Published In/Presented At
Goyal, T., Mitra, S., Khaidakov, M., Wang, X., Singla, S., Ding, Z., Liu, S., & Mehta, J. L. (2012). Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis. Current atherosclerosis reports, Advance online publication. https://doi.org/10.1007/s11883-012-0228-1
Disciplines
Medicine and Health Sciences
PubMedID
22286193
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article