Myopathy Associated With Statins and SGLT2 - A Review of Literature.
Publication/Presentation Date
4-1-2021
Abstract
Drug-induced myopathy is a well-described clinical entity characterized by muscle damage leading to symptoms ranging from myalgias to rhabdomyolysis and acute kidney injury. Many pharmacotherapies are known to precipitate myopathic symptoms. Recent case reports suggest a potential relationship between the use of sodium/glucose cotransport 2 (SGLT2) inhibitors and onset of myopathy. The pathogenesis of this has yet to be elucidated. The relevance of this association is augmented by the recent popularity of SGLT2 inhibitors as well as the tendency for them to be prescribed alongside statins. This study reviewed the literature on the incidence and mechanism of drug-induced myopathy in patients with type 2 diabetes mellitus who are taking SGLT2 inhibitors with and without the use of statins.
Volume
46
Issue
4
First Page
100765
Last Page
100765
ISSN
1535-6280
Published In/Presented At
Gupta, R., Alcantara, R., Popli, T., Mahajan, S., Tariq, U., Dusaj, R. S., & Malik, A. H. (2021). Myopathy Associated With Statins and SGLT2 - A Review of Literature. Current problems in cardiology, 46(4), 100765. https://doi.org/10.1016/j.cpcardiol.2020.100765
Disciplines
Medicine and Health Sciences
PubMedID
33385749
Department(s)
Department of Medicine, Department of Medicine Fellows and Residents, Fellows and Residents
Document Type
Article