Treatment of malignant migrating partial epilepsy of infancy with rufinamide: report of five cases.
Publication/Presentation Date
3-1-2011
Abstract
The syndrome of malignant migrating partial seizures of infancy (MMPEI) is characterized by early onset of multiple seizures types, highly pharmaco-resistant seizures, and overall poor prognosis. In this study, we investigated retrospectively the efficacy of rufinamide (RUF) in five infants with MMPEI, by examining seizure type and frequency, EEG features and antiepileptic drug use. The data demonstrate that two of the five patients showed good efficacy and tolerability for RUF with a > 50% reduction in seizure frequency. The use of RUF for the treatment of MMPEI may therefore provide some hope for such infants and should be further validated. [Published with video sequences].
Volume
13
Issue
1
First Page
18
Last Page
21
ISSN
1294-9361
Published In/Presented At
Vendrame, M., Poduri, A., Loddenkemper, T., Kluger, G., Coppola, G., & Kothare, S. V. (2011). Treatment of malignant migrating partial epilepsy of infancy with rufinamide: report of five cases. Epileptic disorders : international epilepsy journal with videotape, 13(1), 18–21. https://doi.org/10.1684/epd.2011.0406
Disciplines
Medicine and Health Sciences
PubMedID
21393094
Department(s)
Department of Medicine
Document Type
Article