Circadian patterns of generalized tonic-clonic evolutions in pediatric epilepsy patients.
Publication/Presentation Date
9-1-2012
Abstract
OBJECTIVE: To investigate the sleep/wake, day/night, and 24-h periodicity of pediatric evolution to generalized tonic-clonic seizures (GTC).
METHODS: Charts of 407 consecutive patients aged 0-21 years undergoing continuous video-EEG monitoring for epilepsy were reviewed for the presence of GTC evolution. Seizures were characterized according to 2001 ILAE terminology. Charts were reviewed for EEG seizure localization, MRI lesion, and for seizure occurrence in 3-h time blocks, out of sleep or wakefulness, and during the day (6 AM-6 PM) or night. Analysis was done with binomial testing. Regression models were fitted using generalized estimating equations with patients as the cluster level variable.
RESULTS: 71 patients (32 girls, mean age 12.63 ± 5.3 years) had 223 seizures with GTC evolution. Sleep/wake seizure distribution predicted tonic-clonic evolution better than time of day, with more occurring during sleep (p
CONCLUSION: GTC evolution occurs most frequently out of sleep and in older patients. Our results may assist in seizure prediction, individualized treatment patterns, and potentially complication and SUDEP prevention.
Volume
21
Issue
7
First Page
535
Last Page
539
ISSN
1532-2688
Published In/Presented At
Ramgopal, S., Vendrame, M., Shah, A., Gregas, M., Zarowski, M., Rotenberg, A., Alexopoulos, A. V., Wyllie, E., Kothare, S. V., & Loddenkemper, T. (2012). Circadian patterns of generalized tonic-clonic evolutions in pediatric epilepsy patients. Seizure, 21(7), 535–539. https://doi.org/10.1016/j.seizure.2012.05.011
Disciplines
Medicine and Health Sciences
PubMedID
22717517
Department(s)
Department of Medicine
Document Type
Article