Circadian patterns of generalized tonic-clonic evolutions in pediatric epilepsy patients.
OBJECTIVE: To investigate the sleep/wake, day/night, and 24-h periodicity of pediatric evolution to generalized tonic-clonic seizures (GTC).
METHODS: Charts of 407 consecutive patients aged 0-21 years undergoing continuous video-EEG monitoring for epilepsy were reviewed for the presence of GTC evolution. Seizures were characterized according to 2001 ILAE terminology. Charts were reviewed for EEG seizure localization, MRI lesion, and for seizure occurrence in 3-h time blocks, out of sleep or wakefulness, and during the day (6 AM-6 PM) or night. Analysis was done with binomial testing. Regression models were fitted using generalized estimating equations with patients as the cluster level variable.
RESULTS: 71 patients (32 girls, mean age 12.63 ± 5.3 years) had 223 seizures with GTC evolution. Sleep/wake seizure distribution predicted tonic-clonic evolution better than time of day, with more occurring during sleep (p
CONCLUSION: GTC evolution occurs most frequently out of sleep and in older patients. Our results may assist in seizure prediction, individualized treatment patterns, and potentially complication and SUDEP prevention.
Published In/Presented At
Ramgopal, S., Vendrame, M., Shah, A., Gregas, M., Zarowski, M., Rotenberg, A., Alexopoulos, A. V., Wyllie, E., Kothare, S. V., & Loddenkemper, T. (2012). Circadian patterns of generalized tonic-clonic evolutions in pediatric epilepsy patients. Seizure, 21(7), 535–539. https://doi.org/10.1016/j.seizure.2012.05.011
Medicine and Health Sciences
Department of Medicine