Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function.

Publication/Presentation Date

5-1-2005

Abstract

Previous studies from our laboratory have shown that acute alcohol (EtOH) ingestion prior to burn injury enhances intestinal bacterial translocation. This study tested if increased intestinal bacterial translocation in alcohol and burn injured rats is due to an overgrowth in intestinal bacteria. We determined if the translocation was accompanied with alterations in intestinal permeability and immune cell population. Rats (225-250 g) were gavaged with alcohol to achieve a blood EtOH level in the range of 100 mg/dl prior to burn or sham injury (25% total body surface area). Two days after injury, we found that acute alcohol ingestions prior to burn injury results in a significant increase in bacterial counts in small intestine. The increase in intestinal bacterial counts accompanied a significant increase in intestinal permeability. Finally, immunohistochemical analysis revealed a substantial (p

Volume

31

Issue

3

First Page

290

Last Page

296

ISSN

0305-4179

Disciplines

Medicine and Health Sciences

PubMedID

15774282

Department(s)

Department of Medicine

Document Type

Article

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