Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function.
Publication/Presentation Date
5-1-2005
Abstract
Previous studies from our laboratory have shown that acute alcohol (EtOH) ingestion prior to burn injury enhances intestinal bacterial translocation. This study tested if increased intestinal bacterial translocation in alcohol and burn injured rats is due to an overgrowth in intestinal bacteria. We determined if the translocation was accompanied with alterations in intestinal permeability and immune cell population. Rats (225-250 g) were gavaged with alcohol to achieve a blood EtOH level in the range of 100 mg/dl prior to burn or sham injury (25% total body surface area). Two days after injury, we found that acute alcohol ingestions prior to burn injury results in a significant increase in bacterial counts in small intestine. The increase in intestinal bacterial counts accompanied a significant increase in intestinal permeability. Finally, immunohistochemical analysis revealed a substantial (p
Volume
31
Issue
3
First Page
290
Last Page
296
ISSN
0305-4179
Published In/Presented At
Kavanaugh, M. J., Clark, C., Goto, M., Kovacs, E. J., Gamelli, R. L., Sayeed, M. M., & Choudhry, M. A. (2005). Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function. Burns : journal of the International Society for Burn Injuries, 31(3), 290–296. https://doi.org/10.1016/j.burns.2004.09.021
Disciplines
Medicine and Health Sciences
PubMedID
15774282
Department(s)
Department of Medicine
Document Type
Article