Acidic fibroblast growth factor is expressed sequentially in the progression from Barrett's esophagus to esophageal adenocarcinoma.
Acidic fibroblast growth factor 1 (FGF-1) is sequentially accumulated in Barrett's esophagus and its expression in glandular dysplasias is independent of esophageal adenocarcinoma. This suggests that FGF-1 immunohistochemistry could be used as an adjunct to the routine histopathologic diagnosis of dysplasia in Barrett's esophagus. The data also underscore the important role of fibroblast growth factors in tumorigenesis.
Published In/Presented At
Soslow, R. A., Petersen, C. G., Remotti, H., & Altorki, N. (2001). Acidic fibroblast growth factor is expressed sequentially in the progression from Barrett's esophagus to esophageal adenocarcinoma. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 14(1), 23–27. https://doi.org/10.1111/j.1442-2050.2001.00146.x
Medicine and Health Sciences
Department of Medicine