Cocaine-associated acute severe hyponatremia.
Publication/Presentation Date
2-1-2011
Abstract
Cocaine is an indirect sympathomimetic agent that acts in the nervous system to block the presynaptic reuptake of serotonin and catecholamines (dopamine, norepinephrine and epinephrine) and to increase their bioavailability at the post-synaptic receptors. The association of cocaine and hyponatremia has not been reported in adults. We describe a case of acute severe hyponatremia that followed smoking cocaine. We propose that cocaine, via its effect on the neurotransmitters, stimulates antidiuretic hormone release and leads to a syndrome of inappropriate antidiuretic hormone secretion.
Volume
75 Suppl 1
First Page
11
Last Page
15
ISSN
0301-0430
Published In/Presented At
Karim, M. R., Jawairia, M., Rahman, S., Balsam, L., & Rubinstein, S. (2011). Cocaine-associated acute severe hyponatremia. Clinical nephrology, 75 Suppl 1, 11–15.
Disciplines
Medicine and Health Sciences
PubMedID
21269586
Department(s)
Department of Medicine
Document Type
Article