Autophagy modulates lipid metabolism to maintain metabolic flexibility for
Publication/Presentation Date
2-1-2019
Abstract
Loss of tumor suppressor liver kinase B1 (LKB1) promotes cancer cell proliferation but also leads to decreased metabolic plasticity in dealing with energy crises. Autophagy is a protective process involving self-cannibalization to maintain cellular energy homeostasis during nutrient deprivation. We developed a mouse model for
Volume
33
Issue
3-4
First Page
150
Last Page
165
ISSN
1549-5477
Published In/Presented At
Bhatt, V., Khayati, K., Hu, Z. S., Lee, A., Kamran, W., Su, X., & Guo, J. Y. (2019). Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis. Genes & development, 33(3-4), 150–165. https://doi.org/10.1101/gad.320481.118
Disciplines
Medicine and Health Sciences
PubMedID
30692209
Department(s)
Department of Medicine, Fellows and Residents
Document Type
Article
COinS