Immunological profiles in alopecia areata.
Publication/Presentation Date
2-1-1984
Abstract
Cell-mediated immunity and auto-immune phenomena were investigated in sixty patients with active alopecia areata of various degrees of severity. Serum auto-antibodies to thyroid antigens were detected in twenty-three patients. Examination of T-lymphocyte populations, lymphocyte DNA synthesis, and lymphokine production in response to mitogen stimulation revealed no differences between the sixty patients and matched healthy control subjects. However, patients with thyroid auto-immunity and/or the presence of alopecia totalis or universalis showed significant reductions in interactive T lymphocytes (recognized by rosette formation with human B lymphoblastoid cells) and diminished production of leukocyte migration inhibition factor in response to stimulation with phytohaemagglutinin. This suggests that immune mechanisms may be involved in the pathogenesis of alopecia areata which is associated with thyroid auto-immunity or which progresses to total hair loss.
Volume
110
Issue
2
First Page
163
Last Page
170
ISSN
0007-0963
Published In/Presented At
Galbraith, G. M., Thiers, B. H., Vasily, D. B., & Fudenberg, H. H. (1984). Immunological profiles in alopecia areata. The British journal of dermatology, 110(2), 163–170. https://doi.org/10.1111/j.1365-2133.1984.tb07462.x
Disciplines
Medicine and Health Sciences
PubMedID
6607739
Department(s)
Department of Medicine
Document Type
Article