Transformation of CMML to AML presenting with acute kidney injury.
Characterized by bone marrow dysplasia and peripheral blood monocytosis, chronic myelomonocytic leukemia (CMML) is one of the most aggressive chronic leukemias and has a propensity for progression to acute myeloid leukemia (AML). Patients with newly diagnosed AML generally present with symptoms related to complications of pancytopenia but can also present with renal insufficiency. We present a 79-year-old male with a past medical history of CMML and chronic kidney disease stage 3 (baseline creatinine 1.8 mg/dL) who presented with one day of inability to urinate and 20-lb unintentional weight loss, fatigue, and bone pain over 3 months. Laboratory evaluation revealed leukocytosis of 88.5 x 10
Published In/Presented At
DeBoer, R., Garrahy, I., Rettew, A., & Libera, R. (2020). Transformation of CMML to AML presenting with acute kidney injury. Journal of community hospital internal medicine perspectives, 10(4), 353–357. https://doi.org/10.1080/20009666.2020.1774271
Medicine and Health Sciences
Department of Medicine, Department of Medicine Fellows and Residents, Fellows and Residents