Legionnaires' disease: antigenic peculiarities, strain differences, and antibiotic sensitivities of the agent.
Publication/Presentation Date
8-1-1978
Abstract
Paired sera from victims of Legionnaires' disease showed, in many cases, significant rises in immunoglobulin G antibodies to both the causative agent (LA) of Legionnaires' disease and Chlamydia psittaci, but concurrent rises in immunoglobulin M antibodies only against LA. Guinea pigs experimentally infected with LA likewise responded with antibodies to both C. psittaci and LA. Guinea pigs infected with LA also reflected significant differences in antigenic makeup and in pathogenicity among four strains of LA examined. In antibiotic studies, rifampin was 200 times more effective than erythromycin and 17,000 times more effective than tetracycline in plaque reduction tests of LA in monolayer cultures of primary chick embryo cells. An isolate of LA recovered from a healthy person was compared with three isolates from persons with fatal infections.
Volume
138
Issue
2
First Page
260
Last Page
264
ISSN
0022-1899
Published In/Presented At
Ormsbee, R. A., Peacock, M. G., Lattimer, G. L., Page, L. A., & Fiset, P. (1978). Legionnaires' disease: antigenic peculiarities, strain differences, and antibiotic sensitivities of the agent. The Journal of infectious diseases, 138(2), 260–264. https://doi.org/10.1093/infdis/138.2.260
Disciplines
Medicine and Health Sciences
PubMedID
355583
Department(s)
Department of Medicine
Document Type
Article