Niacin-induced hepatitis: a potential side effect with low-dose time-release niacin.
Publication/Presentation Date
1-1-1991
Abstract
Hepatitis developed in five patients who were taking low dosages (3 g/day or less) of time-release niacin. In four of the five patients, clinical symptoms of hepatitis developed after the medication had been taken for a relatively short time (2 days to 7 weeks). This manifestation of hepatotoxicity seems to differ from that previously reported in association with use of crystalline niacin, which occurred with high dosage and prolonged usage of the medication. In view of the recent increased frequency of prescribing niacin for the treatment of hyperlipidemia, physicians should be aware of the potential for hepatotoxicity with even low-dose and short-term use of time-release niacin.
Volume
66
Issue
1
First Page
23
Last Page
28
ISSN
0025-6196
Published In/Presented At
Etchason, J. A., Miller, T. D., Squires, R. W., Allison, T. G., Gau, G. T., Marttila, J. K., & Kottke, B. A. (1991). Niacin-induced hepatitis: a potential side effect with low-dose time-release niacin. Mayo Clinic proceedings, 66(1), 23–28. https://doi.org/10.1016/s0025-6196(12)61171-9
Disciplines
Medicine and Health Sciences
PubMedID
1988755
Department(s)
Department of Medicine
Document Type
Article