Niacin-induced hepatitis: a potential side effect with low-dose time-release niacin.

Publication/Presentation Date

1-1-1991

Abstract

Hepatitis developed in five patients who were taking low dosages (3 g/day or less) of time-release niacin. In four of the five patients, clinical symptoms of hepatitis developed after the medication had been taken for a relatively short time (2 days to 7 weeks). This manifestation of hepatotoxicity seems to differ from that previously reported in association with use of crystalline niacin, which occurred with high dosage and prolonged usage of the medication. In view of the recent increased frequency of prescribing niacin for the treatment of hyperlipidemia, physicians should be aware of the potential for hepatotoxicity with even low-dose and short-term use of time-release niacin.

Volume

66

Issue

1

First Page

23

Last Page

28

ISSN

0025-6196

Disciplines

Medicine and Health Sciences

PubMedID

1988755

Department(s)

Department of Medicine

Document Type

Article

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